Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 28265032.
- Also identified by DOI 10.1136/thoraxjnl-2016-208948.
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Abstract
Hyperpolarised <sup>3</sup>He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6-16 years) with clinically stable mild cystic fibrosis (CF) (FEV<sub>1</sub>>-1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure-function relationships.
Medical subject headings
- Cystic Fibrosis
- Early Diagnosis
- Lung
- Magnetic Resonance Imaging
- Respiration, Artificial