An emerging role for neutrophil extracellular traps in noninfectious disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28267716.
- Also identified by DOI 10.1038/nm.4294.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this process might also occur in noninfectious, sterile inflammation. In this Review, we describe the role of NETosis in autoimmunity, coagulation, acute injuries and cancer, and discuss NETs as potential therapeutic targets. Furthermore, we consider whether extracellular DNA is always detrimental in sterile inflammation and whether the source is always NETs.
Medical subject headings
- Atherosclerosis
- Autoimmune Diseases
- Blood Coagulation Disorders
- Extracellular Traps
- Neoplasms
- Neutrophils
- Wounds and Injuries