Dietary Fat Inflames CD4<sup>+</sup> T Cell Memory in Obesity.
other · Level V
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- Record sourced from PubMed, PMID 28273470.
- Also identified by DOI 10.1016/j.cmet.2017.02.012.
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Abstract
T cells promote inflammation in obesity, but how metabolic stress associated with obesity alters T cell responses remains unclear. In this issue of Cell Metabolism,Mauro et al. (2017) demonstrate that saturated fatty acids directly increase effector-memory T cell formation by amplifying T cell antigen-receptor-induced PI3K/Akt signaling.
Medical subject headings
- Dietary Fats
- Phosphatidylinositol 3-Kinases