Gel or Die: Phase Separation as a Survival Strategy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28283065.
- Also identified by DOI 10.1016/j.cell.2017.02.029.
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Abstract
Stress conditions trigger protein assembly by demixing from the cytoplasm, but the biological significance is still unclear. In this issue of Cell, Riback et al. report that the yeast poly(A)-binding protein 1 (Pab1) is a phase-separating stress sensor that boosts organismal fitness under physiological stress conditions.
Medical subject headings
- Poly(A)-Binding Protein I
- Saccharomyces cerevisiae