Transporters Revealed.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28283067.
- Also identified by DOI 10.1016/j.cell.2017.02.033.
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Abstract
The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.
Medical subject headings
- Membrane Transport Proteins
- ATP-Binding Cassette, Sub-Family C Proteins