BRASSINOSTEROID INSENSITIVE2 negatively regulates cellulose synthesis in <i>Arabidopsis</i> by phosphorylating cellulose synthase 1.
basic_science · Level V
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- Record sourced from PubMed, PMID 28289192.
- Also identified by DOI 10.1073/pnas.1615005114 and PMC identifier 5380027.
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Abstract
The deposition of cellulose is a defining aspect of plant growth and development, but regulation of this process is poorly understood. Here, we demonstrate that the protein kinase BRASSINOSTEROID INSENSITIVE2 (BIN2), a key negative regulator of brassinosteroid (BR) signaling, can phosphorylate <i>Arabidopsis</i> cellulose synthase A1 (CESA1), a subunit of the primary cell wall cellulose synthase complex, and thereby negatively regulate cellulose biosynthesis. Accordingly, point mutations of the BIN2-mediated CESA1 phosphorylation site abolished BIN2-dependent regulation of cellulose synthase activity. Hence, we have uncovered a mechanism for how BR signaling can modulate cellulose synthesis in plants.
Medical subject headings
- Arabidopsis
- Arabidopsis Proteins
- Cellulose
- Gene Expression Regulation, Plant
- Glucosyltransferases
- Protein Kinases