Palladium-catalysed synthesis of triaryl(heteroaryl)methanes.
basic_science · Level V
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- Record sourced from PubMed, PMID 28290445.
- Also identified by DOI 10.1038/ncomms14641 and PMC identifier 5355892.
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Abstract
Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C-C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via a C-H functionalization in good to excellent yield, and represents the first step towards a general transition metal catalysed synthesis of tetraarylmethanes.
Medical subject headings
- Chlorides
- Methane
- Palladium