Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28301471.
- Also identified by DOI 10.1371/journal.pone.0170449 and PMC identifier 5354240.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus sequence typing, and whole genome sequencing identified that donor and recipient VRE isolates were highly similar when compared to time-matched hospital isolates. Comparison of de novo assembled isolate genomes was highly suggestive of transplant transmission rather than hospital-acquired transmission and also identified subtle internal rearrangements between donor and recipient missed by other genomic approaches. Given the improved resolution, whole-genome assembly of pathogen genomes is likely to become an essential tool for investigation of potential organ transplant transmissions.
Medical subject headings
- Genes, Bacterial
- Liver Transplantation
- Tissue Donors
- Vancomycin-Resistant Enterococci