Interaction of renal cortical cyclooxygenase-2 and angiotensin II in postnatal nephrogenesis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 28314575.
- Also identified by DOI 10.1016/j.kint.2016.12.031.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Both renal cortical cyclooxygenase 2 (COX-2) and angiotensin II (Ang II) are involved in postnatal nephrogenesis and maturation. Crosstalk between renal cortical COX-2 and Ang II exists in the adult kidney. However, the potential role of the interaction between renal cortical COX-2 and Ang II in postnatal nephrogenesis and maturation has not been previously investigated. A study by Frölich et al. now strongly indicates that cortical COX-2 promotes postnatal nephrogenesis and maturation through activation of Ang II-angiotensin type 1 receptor signaling.
Medical subject headings
- Angiotensin II
- Cyclooxygenase 2