TRPC6 and kidney disease: sclerosing more than just glomeruli?
Level V
Where this comes from
- Record sourced from PubMed, PMID 28314576.
- Also identified by DOI 10.1016/j.kint.2016.12.033.
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Abstract
Fibrosis is a common response to injury but can also perpetuate tissue dysfunction. Transient receptor potential C6 (TRPC6) is implicated in cardiac and skin healing via regulation of myofibroblast differentiation. Wu et al. now demonstrate a role for TRPC6 in renal fibrosis, via a mechanism that also relies on TRPC3 and is antagonized by soluble klotho. Modulation of TRPC3/6 activity may provide a means of dampening the fibrotic response involved in chronic kidney disease progression.
Medical subject headings
- Fibrosis
- TRPC Cation Channels