Anticoagulation, atrial fibrillation, and chronic kidney disease-whose side are you on?
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 28314578.
- Also identified by DOI 10.1016/j.kint.2016.11.028.
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Abstract
Whether to initiate oral anticoagulant therapy in advanced chronic kidney disease patients with atrial fibrillation remains debatable. Although randomized trial data are lacking, observational studies yield controversial results. Keskar and colleagues analyzed data from a Canadian health care system and found that in elderly chronic kidney disease patients with atrial fibrillation, oral anticoagulant therapy did not prevent ischemic strokes, induced hemorrhages, but prolonged life. These paradoxical findings emphasize the dire need for an adequately powered randomized trial.
Medical subject headings
- Anticoagulants
- Atrial Fibrillation