A proposal for standardized grading of chronic changes in native kidney biopsy specimens.

Sethi, Sanjeev; D'Agati, Vivette D; Nast, Cynthia C; Fogo, Agnes B; De Vriese, An S; Markowitz, Glen S; Glassock, Richard J; Fervenza, Fernando C et al. · Kidney Int · 2017

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Abstract

Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.

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