Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28322850.
- Also identified by DOI 10.1016/j.jaci.2017.02.017 and PMC identifier 8941979.
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Abstract
Regulatory T cells play a critical role in preventing fetal organ-specific autoimmunity in humans. Autopsies of neonatal IPEX patients shortly after birth demonstrate chronic exocrine-dominant pancreatitis with tertiary lymphoid structures containing expanded oligoclonal T/B lymphocytes.
Medical subject headings
- Autoimmunity
- Fetal Development
- T-Lymphocytes, Regulatory