Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd<sup>3+</sup>-Doped Contrast Agent.
basic_science · Level V
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- Record sourced from PubMed, PMID 28323405.
- Also identified by DOI 10.1021/acsnano.7b01297.
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Abstract
Gd<sup>3+</sup>-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r<sub>1</sub> value. Such a strategy is verified on oxygen-deficient PEG-Na<sub>x</sub>GdWO<sub>3</sub> nanorods, which exhibit a remarkable r<sub>1</sub> value up to 80 mM<sup>-1</sup> s<sup>-1</sup> (at 0.7 T) and a high r<sub>1</sub> value of 32.1 mM<sup>-1</sup> s<sup>-1</sup> on a clinical 3.0 T scanner, offering an excellent blood pool MRI performance at a low dose. Meanwhile, free electrons and/or oxygen-vacancy-induced small polarons can endow PEG-Na<sub>x</sub>GdWO<sub>3</sub> nanorods with significant photothermal conversion for MRI-guided photothermal therapy.