Experimental Evolution to Study Virus Emergence.

Grubaugh, Nathan D; Andersen, Kristian G · Cell · 2017

basic_science · Level V

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Abstract

Understanding how viruses adapt to new environments and acquire new phenotypes is critical for developing comprehensive responses to outbreaks. By studying the emergence of vaccine-derived poliovirus outbreaks, Stern et al. describe how a combination of sequence analysis and experimental evolution can be used to reveal adaptive pathways.

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