Rejuvenation by Therapeutic Elimination of Senescent Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28340347.
- Also identified by DOI 10.1016/j.cell.2017.03.014.
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Abstract
In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53's apoptotic role and ameliorates the consequences of senescence-associated loss of tissue homeostasis.
Medical subject headings
- Apoptosis
- Rejuvenation