Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of Castration-resistant Prostate Cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28365160.
- Also identified by DOI 10.1016/j.eururo.2017.03.022 and PMC identifier 5872811.
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Abstract
Bipolar androgen therapy (BAT) is a paradoxical treatment for castrate-resistant prostate cancer whereby testosterone levels are rapidly alternated between supraphysiologic and near-castrate concentrations. Initial studies demonstrated that BAT is safe and produces clinical responses. A trial comparing enzalutamide against BAT is ongoing.
Medical subject headings
- Antineoplastic Agents, Hormonal
- Prostatic Neoplasms, Castration-Resistant
- Testosterone