Maturing of the nuclear receptor family.
review · Level V
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- Record sourced from PubMed, PMID 28368290.
- Also identified by DOI 10.1172/JCI92949 and PMC identifier 5373857.
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Abstract
Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. In humans, genetic mutations in NRs are causes of rare diseases, while hormones and drugs that target NRs are in widespread therapeutic use. The present issue of the JCI includes a series of Review articles focused on specific NRs and their wide range of biological functions. Here I reflect on the past, present, and potential future highlights of research on the NR superfamily.
Medical subject headings
- Genetic Diseases, Inborn
- Mutation
- Receptors, Cytoplasmic and Nuclear