Interferon-β and Interferon-γ Are Weak Inhibitors of Ebola Virus in Cell-Based Assays.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28368541.
- Also identified by DOI 10.1093/infdis/jix134 and PMC identifier 5853567.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Previous studies have demonstrated little efficacy of interferons (IFNs) in animal models of Ebola virus disease. However, these studies were limited to a small number of type I IFNs and, during the most recent outbreak of Ebola virus, questions regarding the suitability of the animal models to evaluate IFNs were raised. To address the potential that anti-Ebola virus activity was overlooked, type I and type II IFNs (α-2a, α-2b, -β, -γ, and -universal) were tested in a variety of cell types (Vero E6, Huh 7 cells, and human macrophages). IFNs are weak inhibitors of Ebola virus Makona in these cell lines.
Medical subject headings
- Antiviral Agents
- Ebolavirus
- Interferon-beta
- Interferon-gamma