GenomeScope: fast reference-free genome profiling from short reads.
basic_science · Level V
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- Record sourced from PubMed, PMID 28369201.
- Also identified by DOI 10.1093/bioinformatics/btx153 and PMC identifier 5870704.
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Abstract
GenomeScope is an open-source web tool to rapidly estimate the overall characteristics of a genome, including genome size, heterozygosity rate and repeat content from unprocessed short reads. These features are essential for studying genome evolution, and help to choose parameters for downstream analysis. We demonstrate its accuracy on 324 simulated and 16 real datasets with a wide range in genome sizes, heterozygosity levels and error rates. http://genomescope.org , https://github.com/schatzlab/genomescope.git . mschatz@jhu.edu. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Computational Biology
- Sequence Analysis, DNA
- Software