Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro-arrayed allergens.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 28369950.
- Also identified by DOI 10.1111/all.13169 and PMC identifier 5638056.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The aim of this study was to investigate possible effects of landscape design on the IgE sensitization profile toward inhalant allergens in patients with respiratory allergy from Uzbekistan where green areas have been changed during the last two decades by a State program. Sera from two different generations of Uzbek (n=58) and, for control purposes, from two generations of Austrian (n=58) patients were analyzed for IgE reactivity to 112 different micro-arrayed allergen molecules by ImmunoCAP ISAC technology. Changes in molecular IgE sensitization profiles to pollen allergens in the young vs the middle-aged Uzbek population were associated with replanting, whereas those in the Vienna populations reflected natural changes in plant growth. Our data indicate that anthropologic as well as natural changes in the biome may have effects on IgE sensitization profiles already from one to another generation.
Medical subject headings
- Allergens
- Epitope Mapping
- Hypersensitivity
- Immunoglobulin E