Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28380367.
- Also identified by DOI 10.1016/j.cmet.2017.03.020.
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Abstract
The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.
Medical subject headings
- Glucagon-Like Peptide 1
- Incretins