A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia.
Level V
Where this comes from
- Record sourced from PubMed, PMID 28380370.
- Also identified by DOI 10.1016/j.cmet.2017.03.014.
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Abstract
During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.
Medical subject headings
- Bile Acids and Salts
- Inflammasomes