Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.
basic_science · Level V
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- Record sourced from PubMed, PMID 28384253.
- Also identified by DOI 10.1371/journal.pone.0175271 and PMC identifier 5383328.
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Abstract
Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness.
Medical subject headings
- Catechin
- Cell Differentiation
- MyoD Protein
- Myoblasts