ESCRTing Necroptosis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28388403.
- Also identified by DOI 10.1016/j.cell.2017.03.030.
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Abstract
Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Medical subject headings
- Protein Kinases
- Receptor-Interacting Protein Serine-Threonine Kinases