Of Mice and Men: Species-Specific Organoid Models of Neocortical Malformation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28388422.
- Also identified by DOI 10.1016/j.stem.2017.03.005.
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Abstract
Cellular changes underlying malformations of human cortical development may be difficult to identify with traditional mouse models. Two recent Cell Stem Cell papers, Li et al. (2017) and Bershteyn et al. (2017), use human cerebral organoids to identify specific cellular defects in neurogenesis that may explain PTEN-related macrocephaly and Miller-Dieker lissencephaly.
Medical subject headings
- Neocortex
- Organoids