TLRgeting Evasion of Immune Pathways in Glioblastoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28388423.
- Also identified by DOI 10.1016/j.stem.2017.03.018.
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Abstract
Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.
Medical subject headings
- Glioblastoma
- Neoplastic Stem Cells