Continued Transmission of Zika Virus in Humans in West Africa, 1992-2016.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 28398562.
- Also identified by DOI 10.1093/infdis/jix182 and PMC identifier 5853591.
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Abstract
First identified in 1947 in Uganda, Zika virus (ZIKV) has remained largely unstudied until the recent outbreak in Latin America. This study aimed to measure the prevalence of ZIKV in febrile patients in Senegal and Nigeria in samples collected from 1992 to 2016. The seroprevalence of ZIKV was 6.2% based on ZIKV immunoglobulin M and negative for dengue reactivity. ZIKV envelope was amplified from 4 samples. Phylogenetic analysis showed that the ZIKVs belonged to the African lineage, grouping with either the Nigerian or MR766 sublineages. This study provides evidence that ZIKV has been silently circulating in West Africa for 2 decades.
Medical subject headings
- Zika Virus
- Zika Virus Infection