Autophagy and renal epithelial transport: eat to survive.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28407874.
- Also identified by DOI 10.1016/j.kint.2017.01.033.
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Abstract
Autophagy is an adaptive cellular response to "stress" in which proteins are targeted for lysosomal degradation. Using a combined proteomics and microscopy approach, Khositseth et al. show that autophagy contributes to the downregulation of the water channel aquaporin-2 in response to hypercalcemia. This commentary discusses the role of autophagy in renal epithelial transport, and explores whether autophagy may also contribute to chronic kidney disease once it becomes dysfunctional.
Medical subject headings
- Autophagy
- Kidney