Endoscopic advanced imaging of the respiratory tract: exploring probe-based confocal laser endomicroscopy in emphysema.
case_control · Level III
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- Record sourced from PubMed, PMID 28411249.
- Also identified by DOI 10.1136/thoraxjnl-2016-209746.
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Abstract
: Probe-based confocal laser endomicroscopy (pCLE) was performed in 15 patients with emphysema and 15 healthy subjects to visualise small airways in a direct and dynamic way. Morphometry shows that the median cross-sectional area of the alveolar openings at the level of the alveolar ducts is significantly larger in emphysema (7.2×10<sup>4</sup> µm<sup>2</sup>) as compared with healthy subjects (5.2×10<sup>4</sup> µm<sup>2</sup>) (p=0.0002). Normalised autofluorescence intensity histograms show a decrease in median autofluorescence intensity (mAFI) in emphysema (p=0.001). mAFI correlates well with Tiffeneau index (r=0.66, p=0.007, 95% CI 0.21 to 0.88). Autofluorescence intensity in emphysema correlates with corresponding data of CT-based quantification. pCLE-based morphometry and autofluorescence intensity analysis in emphysema is able to detect regional changes inside the 'quiet zone'. Results, NCT01204970.
Medical subject headings
- Bronchoscopy
- Microscopy, Confocal
- Pulmonary Emphysema