A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28418672.
- Also identified by DOI 10.1021/acs.nanolett.7b00132 and PMC identifier 5484597.
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Abstract
Ruthenium coordination complexes have the potential to serve as novel theranostic agents for cancer. However, a major limitation in their clinical implementation is effective tumor accumulation. In this study, we have developed a liposome-based theranostic nanodelivery system for [Ru(phen)<sub>2</sub>dppz](ClO<sub>4</sub>)<sub>2</sub> (Lipo-Ru). This ruthenium polypyridine complex emits a strong fluorescent signal when incorporated in the hydrophobic lipid bilayer of the delivery vehicle or in the DNA helix, enabling visualization of the therapeutic agent in tumor tissues. Incubation of MDA-MB-231 breast cancer cells with Lipo-Ru induced double-strand DNA breaks and triggers apoptosis. In a mouse model of triple-negative breast cancer, treatment with Lipo-Ru dramatically reduced tumor growth. Biodistribution studies of Lipo-Ru revealed that more than 20% of the injected dose accumulated in the tumor. These results suggest that Lipo-Ru could serve as a promising theranostic platform for cancer.
Medical subject headings
- Antineoplastic Agents
- Coordination Complexes
- Drug Carriers
- Heterocyclic Compounds, 3-Ring
- Heterocyclic Compounds, 4 or More Rings
- Pyridines
- Ruthenium
- Triple Negative Breast Neoplasms