Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis.

Thompson, George R; Blair, Janis E; Wang, Sharon; Bercovitch, Robert; Bolaris, Michael; Van Den Akker, Dane; Lopez, Rodrigo; Heidari, Arash et al. · Clin Infect Dis · 2017

retrospective_cohort · Level III

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Abstract

Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.

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