Sensing by Smell: Nanoparticle-Enzyme Sensors for Rapid and Sensitive Detection of Bacteria with Olfactory Output.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28423269.
- Also identified by DOI 10.1021/acsnano.7b00822 and PMC identifier 5848077.
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Abstract
We present here a highly efficient sensor for bacteria that provides an olfactory output, allowing detection without the use of instrumentation and with a modality that does not require visual identification. The sensor platform uses nanoparticles to reversibly complex and inhibits lipase. These complexes are disrupted in the presence of bacteria, restoring enzyme activity and generating scent from odorless pro-fragrance substrate molecules. This system provides rapid (15 min) sensing and very high sensitivity (10<sup>2</sup> cfu/mL) detection of bacteria using the human sense of smell as an output.
Medical subject headings
- Bacteria
- Biosensing Techniques
- Candida
- Lipase
- Nanoparticles