Cytomegalovirus Kinetics Following Primary Infection in Healthy Women.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 28431127.
- Also identified by DOI 10.1093/infdis/jix188 and PMC identifier 5461424.
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Abstract
The kinetics of cytomegalovirus (CMV) DNA in infected asymptomatic hosts are largely unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) collected from 21 women who acquired CMV. A quantitative real-time polymerase chain reaction assay of US17, which correlated with clinical assays, was used. VL decreased following primary infection in all fluids. The geometric mean VL of vaginal fluid was significantly higher than that of other sources: oral (3.89; 95% confidence interval [CI], 1.43-10.57), urine (6.36; 95% CI, 2.48-16.32), and whole blood (11.88; 95% CI, 4.12-34.20). Vaginal CMV shedding may provide a route for sexual and possibly perinatal transmission.
Medical subject headings
- Cytomegalovirus
- Cytomegalovirus Infections
- Viral Load