The Search for the Missing Heritability of Prostate Cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28442163.
- Also identified by DOI 10.1016/j.eururo.2017.04.003.
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Abstract
Scientists and clinicians at Johns Hopkins have been working since 1987 to uncover the genetic pathogenesis of prostate cancer. A patient query about the hereditary nature of the disease led to data collection on family history, followed by segregation and linkage analyses. Collaborative investigations using next-generation sequencing to identify genetic variants associated with prostate cancer risk have revealed the significance of HOXB13, BRCA 1/2, and DNA repair mutations.
Medical subject headings
- Biomarkers, Tumor
- Prostatic Neoplasms