Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection.
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- Record sourced from PubMed, PMID 28444306.
- Also identified by DOI 10.1093/infdis/jix194 and PMC identifier 5853778.
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Abstract
Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. Of these women, 71.4% were IgG1+IgG3+, consistent with more recent chlamydia resolution. 15.6% were IgG3- at both visits, suggesting absence of recent chlamydia. Using elementary body ELISA, we demonstrated approximately 1 in 6 women classified as having spontaneous resolution of chlamydia might have been exposed to C. trachomatis but not infected. Further, we classified their possible infection stage.
Medical subject headings
- Antibodies, Bacterial
- Chlamydia Infections
- Chlamydia trachomatis
- Immunoglobulin G