Short lung transplant donor telomere length is associated with decreased CLAD-free survival.
Where this comes from
- Record sourced from PubMed, PMID 28446663.
- Also identified by DOI 10.1136/thoraxjnl-2016-209897 and PMC identifier 6550329.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Telomere length (TL) decreases with cellular ageing and biological stressors. As advanced donor and recipient ages are risk factors for chronic lung allograft dysfunction (CLAD), we hypothesised that decreased age-adjusted donor TL would predict earlier onset of CLAD. Shorter donor TL was associated with increased risk of CLAD or death (HR 1.26 per 1 kb TL decrease, 95% CI 1.03 to 1.54), particularly for young donors. Recipient TL was associated with cytopenias but not CLAD. Shorter TL was also seen in airway epithelium for subjects progressing to CLAD (p=0.02). Allograft TL may contribute to CLAD pathogenesis and facilitate risk stratification.
Medical subject headings
- Graft Rejection
- Graft Survival
- Living Donors
- Lung Transplantation
- Telomere
- Telomere Shortening
- Transplant Recipients