Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 28456387.
- Also identified by DOI 10.1016/j.jpeds.2017.03.053.
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Abstract
In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P = .004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. ClinicalTrials.gov: NCT01913340.
Medical subject headings
- Brain Injuries
- Erythropoietin
- Hypoxia-Ischemia, Brain
- Magnetic Resonance Imaging
- Neuroprotective Agents