Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28459436.
- Also identified by DOI 10.1038/nm.4330 and PMC identifier 5461182.
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Abstract
We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
Medical subject headings
- Alzheimer Disease
- Hippocampus
- Seizures
- Sleep