Basic and Translational Science: A Report from the GRAPPA 2016 Annual Meeting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28461524.
- Also identified by DOI 10.3899/jrheum.170143.
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Abstract
Rapid advances in effective treatments for psoriasis and psoriatic arthritis (PsA) have emerged from improved understanding of cell subsets and critical mediators that promote tissue inflammation and destruction. More specifically, increased knowledge of innate immunity and the important involvement of cytokines in the interleukin (IL)-23-IL-17 axis as key mediators of psoriatic plaque and joint inflammation in both psoriasis and PsA have led to new theories of immunopathogenesis. Herein we summarize recent discussions on IL-17-related pathways and their relationship to psoriasis and PsA.
Medical subject headings
- Arthritis, Psoriatic
- Psoriasis
- Translational Research, Biomedical