Metabolic Flexibility in Health and Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28467922.
- Also identified by DOI 10.1016/j.cmet.2017.04.015 and PMC identifier 5513193.
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Abstract
Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics" technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.
Medical subject headings
- Adipose Tissue
- Diabetes Mellitus, Type 2
- Metabolic Networks and Pathways
- Muscle, Skeletal
- Obesity