Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging.
Where this comes from
- Record sourced from PubMed, PMID 28467943.
- Also identified by DOI 10.1016/j.cmet.2017.04.022.
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Abstract
DNA-dependent protein kinase (DNA-PK), a central player in DNA double-strand break (DSB) repair, shows emerging roles in metabolic regulation. In this issue of Cell Metabolism, Park et al. (2017) elucidate a molecular mechanism whereby DNA-PK negatively regulates AMPK, contributing to metabolic and fitness decline during aging.
Medical subject headings
- Aging
- DNA Damage
- DNA-Activated Protein Kinase