Metabolic Teamwork in the Stem Cell Niche.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28467944.
- Also identified by DOI 10.1016/j.cmet.2017.04.019 and PMC identifier 5627310.
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Abstract
Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth cells provides lactate to drive mitochondrial oxidative phosphorylation in intestinal stem cells.
Medical subject headings
- Intestines
- Metabolic Networks and Pathways
- Paneth Cells
- Stem Cell Niche
- Stem Cells