Molecular Imaging of PARP.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28473593.
- Also identified by DOI 10.2967/jnumed.117.189936 and PMC identifier 5493005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.
Medical subject headings
- Molecular Imaging
- Neoplasms
- Poly(ADP-ribose) Polymerases
- Positron-Emission Tomography
- Radiopharmaceuticals