Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal Genes.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28475876.
- Also identified by DOI 10.1016/j.stem.2017.04.006.
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Abstract
Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel how poised enhancers activate anterior neural genes and the role of Polycomb proteins in enhancer-promoter contacts.
Medical subject headings
- Enhancer Elements, Genetic
- Neurons
- Polycomb Repressive Complex 2
- Promoter Regions, Genetic