Gotta Have GATA for Human Pancreas Development.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28475878.
- Also identified by DOI 10.1016/j.stem.2017.04.004.
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Abstract
Haploinsufficient GATA6 mutations are associated with human pancreatic agenesis. Shi et al. (2017) in this issue of Cell Stem Cell and Tiyaboonchai et al. (2017) in a recent issue of Cell Reports utilize hPSCs to characterize GATA6 function during human pancreas development. One functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation, but it is inadequate for functional β cell differentiation.
Medical subject headings
- GATA6 Transcription Factor
- Pancreas