GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis.
editorial · Level V
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- Record sourced from PubMed, PMID 28475879.
- Also identified by DOI 10.1016/j.stem.2017.04.005 and PMC identifier 5505683.
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Abstract
Hematopoietic stem cells (HSCs) in the bone marrow (BM) form mature blood cells of all lineages through expansion of lineage-biased progenitors. In a recent issue of Nature, Hérault et al. (2017) uncover a unique spatiotemporal mechanism of granulocyte-macrophage progenitors (GMPs) employed in emergency hematopoiesis that is also hijacked in leukemia.
Medical subject headings
- Granulocyte-Macrophage Progenitor Cells
- Hematopoiesis
- Hematopoietic Stem Cells
- Leukemia, Myeloid, Acute