Hematopoiesis: Reconciling Historic Controversies about the Niche.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28475884.
- Also identified by DOI 10.1016/j.stem.2017.03.025.
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Abstract
The niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate.
Medical subject headings
- Hematopoiesis
- Hematopoietic Stem Cells
- Stem Cell Niche