Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28475887.
- Also identified by DOI 10.1016/j.cell.2017.04.030.
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Abstract
Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.
Medical subject headings
- Cell Lineage
- Stem Cells