An Immune Atlas of Clear Cell Renal Cell Carcinoma.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 28475899.
- Also identified by DOI 10.1016/j.cell.2017.04.016 and PMC identifier 5422211.
- Licence recorded as CC BY-NC-ND.
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Abstract
Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls. In 3.5 million measured cells, we identified 17 tumor-associated macrophage phenotypes, 22 T cell phenotypes, and a distinct immune composition correlated with progression-free survival, thereby presenting an in-depth human atlas of the immune tumor microenvironment in this disease. This study revealed potential biomarkers and targets for immunotherapy development and validated tools that can be used for immune profiling of other tumor types.
Medical subject headings
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Tumor Microenvironment